Augmentation index is related to white matter lesions

Significance of age-related white matter lesions.

Extent of cerebral white matter lesions is related to changes of circadian blood pressure rhythmicity.

OBJECTIVE To evaluate the relationship between circadian blood pressure patterns and the extent of cerebral white matter lesions (WML). DESIGN Case-control study. PARTICIPANTS A total of 227 healthy subjects older than 55 years were investigated. Extent and occurrence of WML were evaluated using a computer-supported image analysis system. Circadian blood pressure variation was defined as th...

Reduced white matter integrity is related to cognitive instability.

Increased performance variability has been demonstrated in several groups and conditions, including aging and cognitive decline. Structural brain characteristics underlying this phenomenon have so far been elusive. However, there is reason to expect that disconnectivity in associative pathways, whether caused by immature or degraded white matter (WM) tracts, will increase performance variabilit...

Imaging of white matter lesions.

Magnetic resonance imaging (MRI) is very sensitive for the detection of white matter lesions (WML), which occur even in normal ageing. Intrinsic WML should be separated from physiological changes in the ageing brain, such as periventricular caps and bands, and from dilated Virchow-Robin spaces. Genuine WML are best seen with T2-weighted sequences such as long TR dual-echo spin-echo or FLAIR (fl...

Variability in midlife systolic blood pressure is related to late-life brain white matter lesions: the Honolulu-Asia Aging study.

BACKGROUND AND PURPOSE Although white matter lesions (WMLs) on brain MRI in older persons are common, the mechanisms are unclear. Besides the associations with advanced age and high blood pressure (BP), variability in systolic BP (SBP) and the resulting changes in blood flow to the deep arteries of the brain may be contributing factors. METHODS Japanese-American men in Hawaii have participate...